I know the gene PRNP and it's location. There’s a mutation at codon 178 (asparagine found instead of normal aspartic acid) on the prion protein gene (also found in fCJD) and more uniquely there is a the presence of a methionine at position 129. My question is how PcP(Sc) converts normal PcP(C) into the mutated destructive form, and whether or not this is a reversible process.


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