What's the therapeutic index $\left(\frac{LD_{50}}{ED_{50}}\right)$ of Pethidine (Meperidine in the US) via the intravenous route for humans or whatever species you can find? The therapeutic window $\left(\frac{TD_{50}}{ED_{50}}\right)$ for humans will suffice if accompanied by the therapeutic index for pethidine via IV of another species.

Pethidine is an opioid painkiller with approximately $\frac{1}{7}-\frac{1}{8}$ the strength of morphine and a definite influence on monoaminergic neurons.

I imagine it'd be in the neighbourhood of 30-100, like most opioids that have been implemented in medicine.

  • 1
    $\begingroup$ I don't understand the downvotes. This seems like an answerable question. $\endgroup$
    – kmm
    Feb 12, 2013 at 20:40
  • $\begingroup$ Tell me about it... It would be nice if those that think I've done a poor job in asking this question could tell me what I did wrong. $\endgroup$
    – Josh Pinto
    Feb 13, 2013 at 1:35
  • $\begingroup$ I have not downvoted but perhaps people feel this is a medical question not a biological one. A biologist is unlikely to know the answer, a pharmacist or a surprisingly knowledgeable doctor would. $\endgroup$
    – terdon
    Feb 13, 2013 at 18:13
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    $\begingroup$ Pharmacology is a biologica/biochemical pursuit, not just the purview of medicine or pharmacy. $\endgroup$
    – kmm
    Feb 13, 2013 at 19:23
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    $\begingroup$ If so, where am I supposed to ask this question as far as stackexchange sites? This biology stackexchange is best suited for me to ask this question. $\endgroup$
    – Josh Pinto
    Feb 14, 2013 at 6:29

1 Answer 1


Closest I reached:

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Source: Page 105, The Complete Recovery, By Anthea Hatfield Google Book


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