In my book, there is written something like this. The integral proteins pass into the lipid bilayer to different depths and establish hydrophobic bonds with lipid molecules. Some of the integral proteins run throughout the lipid bilayer. They are called tunnel proteins OR transmembrane proteins. My question is do all the transmembrane proteins have to have channel or tunnel for transport of materials?

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    $\begingroup$ ncbi.nlm.nih.gov/books/NBK26878 Might help dude. Anyway it is quite easy to find something about it and if you dont do a little searching about it nobody will have attempt to answer it. $\endgroup$ – L.Diago May 2 '18 at 12:59
  • $\begingroup$ You know idk what you mean by the material stuff but i think the right answer is just no ! $\endgroup$ – L.Diago May 2 '18 at 13:56
  • $\begingroup$ The substances . $\endgroup$ – Sandeep May 2 '18 at 13:57
  • $\begingroup$ What could it be other than this? $\endgroup$ – Sandeep May 2 '18 at 13:58
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    $\begingroup$ I was asking if all the transmembrane proteins have to be tunnel proteins as it was written in my book . And I think that's not right . $\endgroup$ – Sandeep May 2 '18 at 14:25

Transmembrane proteins don't all have tunnels.

Do all the transmembrane proteins have to have channel or tunnel for transport of materials?

Calling transmembrane proteins tunnel proteins is very misleading. There are a wide range of functions carried out by transmembrane proteins. I'd say the most famous example that don't include a tunnel are the GPCRs that have 7 transmembrane segments. These are used for passing information across a membrane by acting as a receptor to a molecule on one side causing a conformational change which causes an action on the other side of the membrane.

How many transmembrane proteins do have tunnels?

Here is a link to all the GO annotation held by UniProt on transmembrane proteins. There are 10s of millions of results including, but certainly not limited to tunnels and channels.

In the human proteome, there are 831 transmembrane proteins tagged with G-PCR (7TM proteins without a tunnel). The "Transport" keyword, which probably has some sort of tunnel, is present in 1106 transmembrane proteins. In total there are around 5200 human transmembrane proteins in the human proteome.


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