Which enzymes degrade dynorphins and what drugs are there available to inhibit said enzymes?


This paper was looking at inhibition of dynorphin converting enzymes and their importance. Although they don't seem to know if it is a single enzyme, or if it is multiple enzymes.

This paper looked at bikunin as an endogenous inhibitor of dynorphin convertase in human cerebrospinal fluid.

This paper looked at several inhibitors (some of which are known to irreversibly inhibit other enzymes), like N-peptidyl-O-acyl hydroxylamines and their effects on hCSF-DCE, the enzyme that cleaves dynorphin A, dynorphin B and alpha-neoendorphin to release Leu-enkephalin-Arg6. However, it is known to inhibit serine and cysteine proteinases.

However, I don't see any actual medications that are meant to inhibit Dynorphin enzymes. Instead I found Al-Fayoumi et. al were actually looking to identify stabilized dynorphin A derivatives instead of just inhibition of enzymes.

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    $\begingroup$ Although nicely referenced, a list of articles touching on OP's question is not a suitable answer. The answer should be supported by references, a reference list in itself is not an answer. $\endgroup$ – AliceD Jun 10 '15 at 11:31
  • $\begingroup$ I did say at the end of my answer that I hadn't come across any medications that specifically inhibited Dynorphin enzymes @AliceD and pulled from those articles what they had used to inhibit the enzymes. I also noted that hCSF-DCE is the enzyme responsible for cleaving dynorphins. $\endgroup$ – SolarLunix Jun 10 '15 at 13:07
  • $\begingroup$ Yes I agree that your answer is quite complete and I removed my downvote. I do still believe it is not a well-formulated answer, so I will not upvote. $\endgroup$ – AliceD Jun 10 '15 at 13:09

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