A text I am reading says
"GLUT2 is a low-affinity transporter in hepatocytes and pancreatic cells. After a meal, blood travels through the hepatic portal vein and GLUT 2 captures excess glucose for storage.
When concentration drops below Km, much of the remainder bypasses the liver and enters circulation. The Km of GLUT2 is quite high so the liver will pick up glucose in proportion to its concentration in the blood".
I know Km is a measure indirectly of binding affinity.
Rate also is based on concentration so at a higher concentration the rate is higher.
But the passage seems to be saying that at low Km, most of the glucose will not be transported, while at high glucose concentrations, more will be transported.
But i thought Km was a constant so I am confused.