Ketogenesis pathway maps show acetoacetyl-CoA converted to HMG-CoA and only then to the first ketone body acetoacetate. Why this detour instead of directly hydrolyzing off the CoA to get there in a single step? Is it possible that some ketone bodies are made by direct conversion? The enzyme acetoacetyl-CoA hydrolase to do this job exists and can be found in rats.

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    $\begingroup$ I've been Googling this a bit and the trail seems to run dry for the acetoacetylCoA hydrolase after about 1980. I suspect that there is something fishy about it. I notice that the acetyCoA hydrolase turned out to be an alternative activity of the thiolase, and wonder if it is something similar and is not active under the appropriate physiological conditions. There aren’t many biochemists around these days that know about this stuff, and I don’t rate your chances of finding one on this list, but I hope I am proved wrong. Fair question, though. $\endgroup$ – David May 14 '18 at 21:57
  • $\begingroup$ Thanks David for researching this. Too bad we both came up short so far. A future research project hopefully. $\endgroup$ – SeanJ May 18 '18 at 7:21

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