I have a fragment of antibody (Fab) structure, and I know its amino acid sequences of its heavy chain and light chain. As each chain of Fab can be divided into variable and constant regions, how can I know which residues belong to the variable or constant regions?
I can of course look at its 3-D structure in
pymol, but it is difficult to know the belonging of residues between the variable and constant regions.
This link clearly shows how to identify the CDR regions based on its amino acid sequence. Is there a similar way to differentiate variable and constant regions?