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I understand that Dolly the Sheep was created without the presence of a sperm cell. Instead, nucleus DNA from somatic cells of adult sheep were used. Since Dolly was female, i am assuming that the nucleus DNA used came from a female sheep. So, i want to know if the sex of the resulting clone is determined by the sex of the donor animal. Also, in light of the science behind sex determination in clones, would it be theoretically possible to create a male clone where a single woman contributes both the egg and somatic cells used in the cloning process?

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  • $\begingroup$ AFAIK, mammals use sex chromosomes to determine male vs female, with males carrying a copy of the Y chromosome. It is possible to have a male with 1 Y and 2 chromosomes. So, i would guess that if you took a female embryo and microinjected a Y chromosome into the embryo at the single-cell stage, it MIGHT develop into a male. $\endgroup$ – user137 Jun 21 '18 at 13:52
  • $\begingroup$ is there any research that has been done on this topic? $\endgroup$ – ray syoka Jun 22 '18 at 7:52
  • $\begingroup$ I guess not specifically on creating male clones from females, but there have been IVF embyros created using 3 "parents", where one person provided healthy mitochondria to replace the mother's faulty mitochondria. $\endgroup$ – user137 Jun 26 '18 at 5:56
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So, i want to know if the sex of the resulting clone is determined by the sex of the donor animal.

Generally yes for mammals and birds. In animals where the sex is determined by sex chromosomes, the sex of the clone will be dependent by the sex of the donor.

In animals (ie turtles and crocodiles) where the sex is determined by external factors (ie temperature), then the sex of clones will not be dependent on its donor.

would it be theoretically possible to create a male clone where a single woman contributes both the egg and somatic cells used in the cloning process?

Short answer is No.

Sex in mammals and thus humans is dependent on presence or absence of the Y chromosome. If the Y Chromosome is present, the mammal is male. If absent the mammal is female. So a woman does not have the Y chromosome. Hence it is not possible to create a male from her genetic material.

Longer answer... anything is possible. A woman does not have a Y chromosome, so if you added a Y chromosome to one of her ES cells and then used those cells to form the inner cell mass of a blastocyst, then yes you can get a male.

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