It is obvious that cell division in living organisms is now synchronised almost perfectly with DNA replication and, furthermore, the line of division has to intersect exactly the space between the two copies of all the DNA molecules in the cell. I know that as otherwise, most cells would be either empty or have a lot of excess DNA strands, which would lead to an eventual termination of replication due to scarcity of resources and energy required to trigger it.
Some theories (https://www.ncbi.nlm.nih.gov/books/NBK26876/) suggest the first protocell might have formed by a liposome simply gobbling up a self-replicating molecule. However, how would the molecule then 'know':
- when exactly it should replicate so that the replication coincides with the liposome diving and
- where in the molecule it should be located at the time of division, so that its copy ends up in a different daughter cell to itself