The reference below says that a higher AMP/ATP ratio is associated with lower lifespan in C. elegans.
Is this finding also generalizable to vertebrates as well?
Apfeld, J., O’Connor, G., McDonagh, T., DiStefano, P. S. & Curtis, R. The AMP-activated protein kinase AAK-2 links energy levels and insulin-like signals to lifespan in C. elegans. Genes Dev. 18, 3004–3009 (2004). PMCID: PMC535911.