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I guess it has something to do with sugar regulation.

Does anyone know something more about this?

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  • $\begingroup$ please feel free to add relieble source of information for your claim or i think your post is going to be close because now its too opinion based, $\endgroup$ – L.Diago Jun 28 '18 at 12:46
  • $\begingroup$ @L.Diago Every internet site which mentions symptoms when someone quits smoking (nervousness per example) mentions also increased appetite $\endgroup$ – veronika Jun 28 '18 at 14:13
  • $\begingroup$ eje-online.org/content/170/2/219.short $\endgroup$ – L.Diago Jun 28 '18 at 14:16
  • $\begingroup$ But still i would be rather skeptical about this than making some generalization about this phenomenon. $\endgroup$ – L.Diago Jun 28 '18 at 14:18
  • $\begingroup$ @LDiago weight gain is a clear and consistent finding with smoking cessation. Where are you reading that it causes appetite suppression? $\endgroup$ – De Novo Jun 28 '18 at 19:26
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What is the mechanism by which quitting smoking causes increased appetite?

Research has generally focused on weight gain, rather than increased appetite, since it's a more objective outcome.

Smoking cessation has been clearly and consistently shown to be associated with weight gain, in both retrospective and prospective studies, and nicotine replacement seems to reduce some, but not all of the effect, at least while it's used.

There is an excellent, though now aging review of both the effect and potential mechanisms behind a paywall by Filozof. One of the most cited early articles is free at NEJM.

The mechanism of this weight gain is an active area of research, and, as discussed in Filozof, includes increased appetite with associated increase in calorie intake, decreased resting metabolic rate, and decreased physical activity.

Leptin, a hormone that increases both satiety and energy expenditure, is actually increased in people who stop smoking at the same time they are gaining weight. This finding has been convincingly demonstrated and replicated. Leptin insensitivity is a strong candidate for the primary driver of the increase in appetite (and weight gain) after smoking cessation.

Of course, since cigarette smoking causes profound changes in gene regulation, smoking cessation likely does as well. The full answer is almost certainly multifactorial.

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