What is the purpose of the “No DNA control”?

Recently I have done a forensic DNA lab experiment and I still cannot understand the use of “No DNA control”


1 Answer 1


No DNA controls (or water control, also "no sample control") are important to rule out false positives results due to contamination.

If your reagents/pipettes/equipment you use is clean, this reaction (I suppose in PCR) gives you no band. If you have a contamination, this will show up where no band should be and shows that you have a problem. In this case you cannot trust the other results as well.

  • $\begingroup$ Isn't it to know the protein level backgrounds in the given sample? $\endgroup$
    – philip
    Commented Jul 12, 2018 at 15:15
  • 1
    $\begingroup$ This is an instance of the general concept of a negative control -- a very important part of every experiment $\endgroup$
    – De Novo
    Commented Jul 12, 2018 at 15:30

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