It is known that cancerous tumors in humans can develop hypoxic regions where no blood nor oxygen arrive to some volume of its cells, creating a dead lump inside or around the tumor. See Wikipedia - Tumor hypoxia.

  • Are hypoxic regions and regions without blood supply are more common in large tumors than in small tumors?
  • What is the likelyhood or frequency of hypoxic regions in small (< 2 cm) and large (> 4 cm) tumors?
  • What is the typical size of an hypoxic region within a tumor?

The article in Wikipedia is too techincal and very hard to be read and understood, and doesn't have an explicit answer to my question.

  • $\begingroup$ This isn't a direct answer because it's more of a model system in vitro, and wouldn't model in the in vivo microenvironment, but it's interesting to look at Table 1. ncbi.nlm.nih.gov/pmc/articles/PMC4764677 $\endgroup$
    – CKM
    Jul 16 '18 at 0:46

The prescence of hypoxia is independent of size, grade, or histology. It occurs due to a cut off in blood supply to the tumour. Or insufficient vasculature systems, meaning the oxygen cannot diffuse all the way into the tumour. Aberrant growth of tumours can increase the likelyhood of tumours developing hypoxic regions.

  • $\begingroup$ Hypoxic region can be formed in any tumor, big or small. But does large tumor have significantly larger hypoxic regions? $\endgroup$ Jul 17 '18 at 7:29
  • 1
    $\begingroup$ Not necessarily. Its all tumour dependant. $\endgroup$
    – pazchem
    Jul 17 '18 at 7:36
  • $\begingroup$ And statistically? $\endgroup$ Jul 17 '18 at 8:26
  • $\begingroup$ There is no relationship. The paper titled: "Detection and Characterization of Tumor Hypoxia Using pO2 Histography," looked at several tumor types none of which have a correlation between size and hypoxia. $\endgroup$
    – pazchem
    Jul 17 '18 at 10:09

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