It is known that cancerous tumors in humans can develop hypoxic regions where no blood nor oxygen arrive to some volume of its cells, creating a dead lump inside or around the tumor. See Wikipedia - Tumor hypoxia.
- Are hypoxic regions and regions without blood supply are more common in large tumors than in small tumors?
- What is the likelyhood or frequency of hypoxic regions in small (< 2 cm) and large (> 4 cm) tumors?
- What is the typical size of an hypoxic region within a tumor?
The article in Wikipedia is too techincal and very hard to be read and understood, and doesn't have an explicit answer to my question.