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In the example of a retrovirus, after the lipid bilayer fuses with the membrane of the cell, the capsid dissolves releasing the viral content.

What is the mechanism behind the capsid dissolving? I know the protomers are proteins which make up the capsid and they are held together by non-colvelent bonds --- is there some type of reaction due to change in pH that drives this event?

Thanks.

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  • $\begingroup$ I'm no virology expert and I'm pretty sure there isn't one universal answer for all (retro)viruses to this question, but pH change (remember that fused viral particles will end up in the endo-lysosomal compartments) is a major factor in many cases $\endgroup$ – Nicolai Aug 7 '18 at 14:19

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