Cardiac muscle has got a central nucleus similar to smooth muscle, but skeletal muscle you may recall has got many many peripheral nuclei.

What does "peripheral" mean here?

  • $\begingroup$ Maybe you can add the source of the citation to have a clearer context $\endgroup$
    – have fun
    Aug 12, 2018 at 13:37
  • $\begingroup$ @havefun More info added $\endgroup$
    – a.RR
    Aug 12, 2018 at 15:30
  • $\begingroup$ Skeletal muscle nucleui are peripheral located because they have a large muscle tone compared to the cardiac and smooth muscles. $\endgroup$ Feb 17, 2019 at 18:43

1 Answer 1


'Peripheral' in this context refers to the position of the nuclei within the skeletal muscle cell. They are in the periphery (outer part) of the cell body rather than central as in most cell types. More specifically, they are "subsarcolemmal", i.e. just under the sarcolemma, the cell membrane of the muscle fiber cell (source):

Nucleus in skeletal muscle (Wikipedia)

(Image from Wikipedia)

The many nuclei of a skeletal muscle cell are spaced out along the length of the cell (source 1, source 2).


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