What does "Psychomodulatory" mean in the context of potentially psychoactive drugs? That is, in this journal article http://www.sciencedirect.com/science/article/pii/S0028390812001931 in the discussion (you will need special privileges to access the article via an institute or personal subscription or by paying for access) in the last sentence of the first paragraph it says

However, euphol even when given in very high doses, (up to 100 mg/kg) it did not show any evidence of psychomodulatory effects in the CNS


To me, "psychomodulatory" would mean "eliciting a significant change (up or down) relative to baseline or compared to a control, placebo, or carrier," here specifically in CNS function.

This statement appears to refer to the results presented in section 3.8, Effect of euphol in the cannabinoid tetrad tests. Across a range of doses (3-100 mg/kg) and across four different assessments of CNS function: locomotor activity (rotarod), catalepsy (time to move off of a suspended ring), analgesia (tail flick in response to thermal stress), and body temperature (self explanatory). The results of these four are summarized in the figure below.

Results of four tests of CNS function

Basically the effects are not significantly different from each other between dosages or times. The lines sit more or less atop one another. Compare to this figure, where the differences are significant:

enter image description here


Your Answer

By clicking “Post Your Answer”, you agree to our terms of service, privacy policy and cookie policy

Not the answer you're looking for? Browse other questions tagged or ask your own question.