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The action of mucosal phospholipases hydrolyzes luminal lecithins to toxic lysolecithins. The normally protective glycoprotein mucus layer is disrupted, exposing the mucosal epithelium to the direct detergent action of bile salts. (source: Robbin's textbook of pathology, pgno:878, 9e)

also this video says that due to obstruction the mucosa releases enzymes( presumably phospholipase).


Why does gallbladder mucosa secretes an enzyme which exacerbates the condition?

Does secretion of phospholipase serve any physiological(protective) function in case of obstruction( other than due to gall stones)?

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