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Scientists how to prove DNA is anti-parallel?

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    $\begingroup$ Hello and welcome to Bio.SE! Take the tour to learn about the site and earn yourself your first badge. Also, we require questions to show the previous efforts looking for an answer. What did you already do in order to find experiments for anti-parallel DNA? $\endgroup$ Oct 12, 2018 at 6:38
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    $\begingroup$ @LinuxBlanket i still think thats only homowork. :) $\endgroup$
    – L.Diago
    Oct 12, 2018 at 7:00
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    $\begingroup$ @L.Diago I know, but let's know them the site policy :) $\endgroup$ Oct 12, 2018 at 7:09

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The definitive proof came with the crystal structure of B-DNA (see Watson & Crick, 1953). Anti-parallel strands is the configuration that best explained the diffraction data while not violating chemistry (bond lengths and angles, no steric clashes, etc.).

The relevant sentence from the article is:

the sequences of the atoms in the two chains run in opposite directions

I underlined this sentence in the following screenshot of the article:

DNA structure

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    $\begingroup$ Why are you answering homework questions that clearly do not satisfy SE Biology criteria as two comments make clear. Doing so encourages cheats and people too idle to do any research of their own. $\endgroup$
    – David
    Oct 12, 2018 at 22:44
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    $\begingroup$ Because I am not convinced it's a homework question. Assuming it is a homework question, it's a poorly formulated one anyway because the article containing the answer is behind a paywall, even on campus at a US university (I just checked where I work), which means no student would realistically find the answer on their own easily. $\endgroup$
    – Guillaume
    Oct 12, 2018 at 23:18
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    $\begingroup$ Whether or not you think the question was homework, @LinuxBLanket had explained the deficiency of the question. It is reasonable to expect the OP to respond this (and the comment about home work), and to wait until he has done so before answering. As for the unavailability of the original Watson and Crick paper, this is described in every book on biology, and is available on line in a far more comprehensible form to the student. I would wait until there is a request for access to original sources before posting, and then do so in a form that does not discriminate against the partially sighted. $\endgroup$
    – David
    Oct 13, 2018 at 13:29
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    $\begingroup$ You're right about accessibility: I should have retyped the sentence instead of posting a screenshot (the PDF is a scan from which I couldn't copy text, and I was lazy, hence the screenshot). Will edit the answer accordingly. Now, I disagree with the rest of your comment: answers on SE are public and therefore potentially useful to anybody (not only the OP), who would never find the information because it's behind a paywall. $\endgroup$
    – Guillaume
    Oct 14, 2018 at 3:45
  • $\begingroup$ Agreed about "at this point", but now their interpretation has been confirmed experimentally more than 5000 times: rcsb.org/pdb/results/… $\endgroup$
    – Guillaume
    Oct 14, 2018 at 20:33

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