When a person with Bipolar Disorder ingests a pill of $\ce{Li_2CO_3}$ and it enters the stomach the pill cap is dissolved in the hydrochloric acid; however, when it gets absorbed in the blood how does it dissociate? Does it dissociation is there an enzyme, is that enzyme Carbamoyl phosphate, or is it the blood that separate them. Thank you. I have also been reading biochemistry books, and would be willing to cite the information that lead me to guess.


Data for Biochemical Research Third Edition

Rex M.C. Dawson, Dophne C Elliot

The book notes that the enzyme does 100 percent hydrolysis of $\ce{Li_2}$ salt in 2 min. at 100 degrees Celsius, 50 percent in 2 hours at 30 degrees Celsius.

This confused me because lithium carbonate is a salt. So I was confused. Thanks again.

  • $\begingroup$ Do you have any resorses or how did you make it up? $\endgroup$ – L.Diago Oct 12 '18 at 21:10
  • $\begingroup$ @L.Diago Yes let me add them $\endgroup$ – EnlightenedFunky Oct 12 '18 at 21:16
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    $\begingroup$ Carbamoyl phosphate is not an enzyme but a compound (but carbamoyl phosphate synthase is an enzyme); the data given by Dawson in DFBR refers to the stability of the di-lithium salt of this compound. But you are right, lithium carbonate is a salt and will be fully dissociated in aqueous solution. (As as student I had a job measuring serum lithium concentrations. The concentration in serum (the 'liquid' obtained when clotted blood is centrifuged) 24-hours after taking a lithium tablet could be as high as 1mM (> 1.5mM considered toxic), but presumable levels are much higher after ingestion) $\endgroup$ – user1136 Oct 12 '18 at 23:57
  • $\begingroup$ Are you asking about some quote in a book? Because the uncertainty in the question about salts is a bit confusing (i.e., if you know what a salt is, and how it works in water, it's unclear what your question is). It might be better to reproduce the actual quote here. $\endgroup$ – Bryan Krause Oct 13 '18 at 6:10
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    $\begingroup$ In the section on "Phosphate esters excluding nucleotides and coenzymes", the 'general remark' of Dawson on carbamoyl phosphate: "100% hydrolysis of Li(2) salt in 2 min at 100 degrees C in water, in 10 min at RT in 0.1M alkali...." This refers to the stability of carbamoyl phosphate in solution. Breakdown is non-enzymic, and has nothing whatsoever to do with the stability of lithium carbonate (which in solution will be fully dissociated, and (probably) stable indefinitely). $\endgroup$ – user1136 Oct 13 '18 at 8:58

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