Soap molecules are similar in structure to phospholipids and interact with the cell membrane. They can clearly cause damage to the cell membrane.

If this is the case, why then, does soap not break down your skin every time you use it? The skin cells, keratinocytes still have a membrane, so wouldn't soap attack our skin in the same way it does to plant cells and cause deterioration?

  • $\begingroup$ You know skin has really complicated structure. It really depents on what do you mean by break down skin. Did you mean by this something like tear it a part ?? $\endgroup$
    – L.Diago
    Oct 26, 2018 at 9:16
  • 4
    $\begingroup$ @L.Diago I think this is an interesting question. Soap destroys lipid bilayers. What structures/mechanisms exist in the skin that prevents the destruction of our own cells? $\endgroup$
    – James
    Oct 26, 2018 at 11:48
  • $\begingroup$ @James i just want to know what did he mean by break down your skin. If he want to know why does his skin is not damaged after he used soap i rather recommened to study some basic anorganic and organic chemistry. $\endgroup$
    – L.Diago
    Oct 26, 2018 at 12:46
  • $\begingroup$ Still it is not biological problem rather chemistry problem. By chemical point of view its just a combination on neutralization of pH from NaOH, and saturation of fatty acid by NaOH. $\endgroup$
    – L.Diago
    Oct 26, 2018 at 12:48
  • 3
    $\begingroup$ @LDiago it's exactly a biological problem (how does soap interact with mammalian skin). If you want to be reductive, you could say any biological problem is either a physics problem, a math problem, or both. $\endgroup$
    – De Novo
    Oct 27, 2018 at 5:38

2 Answers 2


The outer most layer of the mammalian epidermis (cornified layer or stratum corneum) is composed of 15-20 layers of dead cells called corneocytes, which are basically dead keratinocytes filled with keratin intermediate filament cross-linked other proteins as well as some lipids. As keratinocytes differentiate into corneocytes (a process called cornification), the plasma membrane is replaced by what is called a conified envelope which is composed of cross-linked structural proteins and some lipids (more details in here).

Surfactants in soap do interact with components of the cornfield layer such as keratin but not in the same way they would with the lipid bilayer of a typical plasma membrane. Outcome of such interaction depends on the kind of soap as well as amount and duration of application among other factors, but even a normal soap, upon normal use on a normal skin, may cause some keratin denaturation. But the cornified layer is actually continually shed (process called desquamation) and replaced by keratinocytes that proliferate in the inner most layer of the epidermis.

You can find more details on effect of detergents on skin here and here. You can also find useful info on skin structure here and here.

  • $\begingroup$ So is the answer that soap does break down your skin, but just a little bit and it gets replaced quickly? $\endgroup$
    – 425nesp
    Apr 1, 2020 at 9:35


"The SC [stratum corneum] consists of corneocytes, keratinocytes that have undergone terminal differentiation, surrounded by a neutral lipid-enriched, extracellular matrix composed primarily of ceramides, cholesterol, and free fatty acids. The hydrophobic extracellular lipid matrix provides the principal barrier to the transcutaneous movement of water and electrolytes."

The keratinocytes have an extracellular ground substance that basically bar things like soap and water from diffusing/otherwise entering the body; this is even a part of our innate immune system. The answer then is the keratinized stratified squamous epithelial extracellular matrix.


You must log in to answer this question.

Not the answer you're looking for? Browse other questions tagged .