I was reading recently about prion disease and it caught my attention that a normal prion protein is coded n chromosome 20, therefore, in order for an infectious prion protein to attack, there must be already normal unsedimented prion proteins, does that mean the deletion of chromosome 20 in meiosis lead to immunity against prion disease, since the protein is not coded, that is if the human survives without chromosome 20
I see one report of a viable autosomal monosomy,
but in general, they are not survivable.
A better question would be if person with a deletion or natural knockout of that gene are susceptible to that prion disease. Those subjects likely exist in larger numbers, though it's likely that few have been exposed to any particular prion disease.