the delta G0 of hydrolysis for two terminal phosphate group is around 7.3Kcal/mol, so why does ATP not breakdown spontaneously? Is it because it has high activation energy?

  • $\begingroup$ It does hydrolyzes spontaneously. $\endgroup$ – BPinto Nov 6 '18 at 2:21
  • $\begingroup$ If it did then how do you expect all the biochemical reactions to take place at physiological pH that require ATP hydrolysis at the specific step of a metabolic pathway. Life would not exist as we know if all the ATP spontaneously hydrolysed $\endgroup$ – Anindya Nov 6 '18 at 3:42
  • $\begingroup$ Depending on conditions such as pH and temperature the hydrolysis can take hours or days. These time scales are ok for biochemical reaction. $\endgroup$ – BPinto Nov 6 '18 at 12:59
  • $\begingroup$ Please read a biochemical textbook such as Berg at NCBI online to learn about enzyme catalysis, activation energy and the thermodynamics of reactions. This is a basic concept that appears in dozens of answers on this list. $\endgroup$ – David Nov 6 '18 at 20:28
  • $\begingroup$ David I do know about enzyme catalysis anf thats exactly why i asked the question in the first place, i was unsure 9n hiw exactly ATP could remain long enough in the system to be utilised by other biochemical reactions.. one thing that came to my mind was probability of it having high activation energy which could answer why it will only be used in enzyme catalysed reactions. $\endgroup$ – Anindya Nov 6 '18 at 20:46

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