I am reading the textbook Biology (Campbell et al, 2005), and I am confused.

In Chapter 6.4, on page 104, it says that "In the smooth ER, other enzymes help detoxify drugs <...>", and alcohol is mentioned later.

In Chapter 6.5, on page 111, it says "Peroxisomes in the liver detoxify alcohol <...>"

Googling the question also brought me mixed results.

As I understand it, alcohol detoxification happens in two stages, first oxidising ethanol to the also toxic ethanal, and then oxidising ethanal to acetic acid.

Do these processes happen in different organelles? Is that the reason that both of them are mentioned? Or do they both detoxify alcohol completely, but do it in different circumstances?


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