I've heard that it's got to do something with the levels of cortisol which usually dampens the effects of IL-1, but when it's night time the cortisol levels are usually low so IL-1 response is exaggerated.

But why does it occur to a greater extent in diseases like TB and lymphoma? Why is the interleukin 1 effect during night so much greater in these diseases than in case of other viral and bacterial infections?

  • $\begingroup$ Where are you getting the idea that temperature doesn't tend to increase at night with other illnesses? $\endgroup$ – Bryan Krause Nov 28 '18 at 5:01
  • $\begingroup$ @BryanKrause night sweats are a typical, and at times dramatic symptom characteristic (but not diagnostic) of TB, endocarditis, and certain cancers. I'm not aware of data on the how the mechanism is different from typical fever produced by IL-1 myself. I would say this is a good question. $\endgroup$ – De Novo Nov 28 '18 at 6:18
  • $\begingroup$ Of note, there are other instances where fever has a periodicity to it. The quotidian fever of malaria comes to mind, but if I recall, that's associated with the life cycle of the parasite. $\endgroup$ – De Novo Nov 28 '18 at 6:21
  • $\begingroup$ @DeNovo But isnt body temperature itself also circadian, with fevers from just about every cause following this cycle (exceptions being anything with an onset or resolution too fast to see it)? $\endgroup$ – Bryan Krause Nov 28 '18 at 15:00
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    $\begingroup$ OP, I've edited this question to focus on why the nightly increase in temperature is exaggerated in these particular disease (rather than why it occurs at all, since you seem to already have a handle on why it occurs in the general case). @BryanKrause I see your point. I've edited to make it a better question. $\endgroup$ – De Novo Nov 28 '18 at 17:54

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