I have absolutely no idea as to how Levomepromazine elicits its analgesic effects so please do direct me to journal articles and other credible sources with you, the answerer, making a summary of Levomepromazine's mechanism of action in your answer.


According to Drugbank and the articles cited below, Levomepromazine is an antagonist of several different receptors: These include dopaminergic 2, dopaminergic 4, alpha-1 adrenoceptor, 5HT-2, histamine type 1 and muscarinic-cholinergic receptors.


  1. Evidence for the use of Levomepromazine for symptom control in the palliative care setting: a systematic review
  2. Muscarinic cholinergic and histamine H1 receptor binding of phenothiazine drug metabolites
  3. Levomepromazine receptor binding profile in human brain—implications for treatment—resistant schizophrenia
  4. Phenothiazine drug metabolites: Dopamine D2 receptor, α1-and α2-adrenoceptor binding

Your Answer

By clicking “Post Your Answer”, you agree to our terms of service, privacy policy and cookie policy

Not the answer you're looking for? Browse other questions tagged or ask your own question.