There is a lot of work being done on developing small nanomechanical structures and even small nanomechanical actuators built with DNA. I have heard researchers motivate this research with claims that it could have biomedical applications. My question is, how likely is this to be true? In particular, a few potential problems bother me:
(1) What is the risk that the foreign DNA strands used to build nanomechanical devices will be accidentally incorporated into the host genome? Are there plausible strategies for avoiding this?
(2) Will it be effective in the presence of an immune system? If the foreign DNA is not incorporated into the host genome, it seems likely to instead be destroyed by the host immune system. Is there research addressing this issue?