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Parts of our brains and bodies 'lock' after various critical periods. What keeps those body parts locked after the critical period closes?

For example, our limbs stop growing at a certain length or our brains lose plasticity to acquire some specific skills. We've seen experimental data with valporic acid and other hdac inhibitors re-open critical periods in the brain [1]. Is this the same mechanism (histone deacetylation) by which brain structures or limbs are locked into place?

  1. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3848041/
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