I have been taught that hypotonia is always caused by lower motor neuron lesions while hypertonia is by upper motor neuron lesions. However, I recently learned of an entity called central hypotonia, which means hypotonia caused by a central nervous system lesion. This makes it so confusing.

  • $\begingroup$ UML leads to disuse, this can also cause disuse atrophy and hense hypotonia. $\endgroup$ – Anubhav Goel Jan 9 at 19:30

The rule-of-thumb you (and I) were taught reflects the role of the central and peripheral nervous systems in establishing muscle tone. Deprived of CNS regulation, alpha motor neurons increase in their responsiveness to spindle afferents, resulting in hypertonia. Deprived of PNS regulation, muscle spindles are less able to react to input, resulting in hypotonia.

Beyond this rule-of-thumb, things aren't as black-and-white. As you have pointed out, there is such a condition as central hypotonia. In fact, the NINDS includes the CNS as an area where damage can cause hypotonia:

"Hypotonia can happen from damage to the brain, spinal cord, nerves, or muscles." (source)

Purves et al. also note that upper motor neuron syndrome involves an "initial period of 'hypotonia' after upper motor neuron injury" (Neuroscience, 2012, p. 395).

To your question: Yes, the rule-of-thumb is not always accurate and upper motor neuron lesions can cause hypotonia.

If you're looking for a hypothetical mechanism, consider this: Purves et al. also state that hypertonia is "probably caused by the removal of suppressive influences exerted by the cortex" (p. 396). So it is conceivable that overstimulation of these inhibitory control systems by some sort of unique upper motor neuron lesion could result in hypotonia.

  • $\begingroup$ But in Down's syndrome there is no "initial phase" and the hypotonia actually persists as central hypotonia. The mechanism is not the same right? $\endgroup$ – wilsonw Dec 26 '18 at 3:41
  • 1
    $\begingroup$ For Down’s Syndrome, I might not actually call it “central” hypotonia because it’s a genetic disorder. This does suggest that the mechanism is different, though. But even in neurologically-triggered instances I would expect there to be mechanistic nuances that could break the rule (leading to chronic central hypotonia). $\endgroup$ – André Nelson Dec 26 '18 at 16:12

Your Answer

By clicking “Post Your Answer”, you agree to our terms of service, privacy policy and cookie policy

Not the answer you're looking for? Browse other questions tagged or ask your own question.