2
$\begingroup$

I am trying to find homologs for some proteins and I am wondering if it is better to find it by comparing the proteins or the coding genes or either is fine.

$\endgroup$
  • 1
    $\begingroup$ Think. What is likely to be more conserved — protein sequence or nucleotide sequence? $\endgroup$ – David Dec 30 '18 at 11:17
3
$\begingroup$

In most* scenarios you will probably want to look at a comparison of proteins following some additional matching that considers more than a single gene/protein. Luckily, this is a very common problem and one can often look up homologs through existing reference databases such as https://www.ncbi.nlm.nih.gov/homologene

Further, if genes are not present, their documentation will provide a good overview on ways to find homologs in other organisms.

*in some very special scenarios, gene sequences might be more suitable. For instance if one wanted to study similarity of non-coding regions of a gene. However these exceptions would seem beyond the general character of the question.

$\endgroup$

Your Answer

By clicking “Post Your Answer”, you agree to our terms of service, privacy policy and cookie policy

Not the answer you're looking for? Browse other questions tagged or ask your own question.