I have been reading a book ( Statistics for Biology and Health) and i encountered many of following bold text.
- Consider a long DNA sequence of length N, where N is assumed to be so large that end effects can be ignored in our calculations.
In Shotgun sequencing also the saw similar thing :
- The fragments are assumed to be taken at random from the original full-length sequence, so that if end effects are ignored, the left-hand ends of the fragments are independently distributed with a common uniform distribution over [0,G].
What does " end effects can be ignored " means?