I am wondering for prokaryotes if Deutrium Oxide could be made into Deutrium Glucose or other biological compounds with Deutrium.
Yes, this is possible and inter alia used to clarify biosynthetic pathways.
For example in this study. Rats were given deuterated water and the average number of D atoms incorporated in cholesterol and fatty acids was determined. Also deuterium was found in plasma glucose and liver lactate and pyruvate.