I heard Colchicine doubles the chromosome count; I read about that and I understand why but can you guys explain how?
Colchicine binds to tublin and therefore inhibits the polymerization of microtuble. That way the build-up of the mitotic spindle, necessary for the separation of the chromosomes in the metaphase of mitosis, is inhibited. Therefore, during cell division, one cell remains without any genetic material, while the other cells receives a double chromosome set. While this leads to cell death for animal cells in both cases, in plant cells multiple chromosome sets can have beneficial effects.