2
$\begingroup$

Would some inhibitors of viral enzymes work against common cold viruses? Are there any studies? What could a treatment look like?

A lot of common cold viruses are rhino viruses which are picorna viruses. All picorna viruses contain two cysteine proteases, designated 3C and 2A according to Handbook of Proteolytic Enzymes Volume 2, 2013, Pages 2402-2406 David S.Wishart Would it suffice to inhibit either of them?

$\endgroup$
  • $\begingroup$ Common cold seems like the most damaging disease of all. With on average two weeks sickness per year and person that equals to an annual loss of GDP by 300 billion EUR in EU. $\endgroup$ – David Jonsson Feb 25 at 18:07
  • $\begingroup$ I will only accept an answer which inhibits an enzyme from a virus, not a human enzyme. $\endgroup$ – David Jonsson Jun 10 at 15:46
2
$\begingroup$

A human enzyme involved in the production of rhinovirus capsids has been successfully inhibited.

Fragment-derived inhibitors of human N-myristoyltransferase block capsid assembly and replication of the common cold virus https://www.nature.com/articles/s41557-018-0039-2

The article also says that targeting a human enzyme could be more efficient since the risk of mutation is lower compared to a virus enzyme.

$\endgroup$

Your Answer

By clicking “Post Your Answer”, you agree to our terms of service, privacy policy and cookie policy

Not the answer you're looking for? Browse other questions tagged or ask your own question.