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I'm a physicist and I'm interested in hypoxia due to the lack of nutrients at the center of avascular tumors. So I have a few questions about hypoxia.

Below which concentration of oxygen and other nutrients in a tissue is there hypoxia and cells start to necrose ?

Are these value connected to the network of vessels in the tissues, and is this network optimal ?

And what is the typical values for the concentration of oxygen in the body ?

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