We learned that Cytotoxic T cells are MHC dependent, and if CMH matchup doesn't occur between the T cell and the cancer cell for example, the former won't attack the latter. If this is the case then how are T cells given through vaccines and transfers?


T cells are not transferred. Vaccines induce the host to expand their own T cells that are responsive to the antigens that are given.

  • $\begingroup$ Adoptive cell transfer incl. TIL and CAR-T are forms of T cell transfers, though. $\endgroup$
    – CKM
    Feb 11 '19 at 14:43
  • $\begingroup$ First, they're still almost invariably autologous, and second, given that the question seems to come from a fairly naive viewpoint it doesn't seem worth confusing the issue. If the OP would like expansion on these, they should clarify the question. $\endgroup$
    – iayork
    Feb 11 '19 at 15:57
  • $\begingroup$ I thought the same thing, fair enough. $\endgroup$
    – CKM
    Feb 11 '19 at 15:59

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