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I'm aware direct translation of DNA to protein (without the need for RNA) has been observed in test-tubes using e-coli. (Reference: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC219759/) I wanted to know whether there have been any natural cases for this that have been observed. And suppose there aren't, would it be theoretically possible in a cellular environment?

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  • $\begingroup$ Please provide a reference for your assertion. But in any case the answer is NO. Why do you think the complex system that exists developed? $\endgroup$ – David Feb 15 '19 at 20:16
  • $\begingroup$ I have edited the post to provide a reference. $\endgroup$ – ennui Feb 15 '19 at 20:44
  • $\begingroup$ OK. You should consider whether the technology used in that work over 50 years ago was able to demonstrate and compare it with your assertion. $\endgroup$ – David Feb 15 '19 at 20:50
  • $\begingroup$ I'm aware that RNA is of course an essential role in molecular biology for almost all complex systems as far as I know. Its importance to biology is unquestionable. However, the reason I asked this question in the first place was from reading Crick's Central Dogma of Biology article (cs.brynmawr.edu/Courses/cs380/fall2012/…). In it, while he ruled any transfers from Protein to nucleic acids impossible, he argues that while there is no evidence for direct DNA to protein translation nor is it impossible either. $\endgroup$ – ennui Feb 15 '19 at 20:56
  • $\begingroup$ But that was 60 years ago. It’s of historical interest — no more. Do you realize how little was known at the time? $\endgroup$ – David Feb 15 '19 at 21:00

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