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Without cosmetic surgery or etc., are there any cases/example wherein a human adult has had a change in significance regarding these regions of the face? I have seen many anecdotes where people have asserted that certain things (not surgery) like diets, drugs, or etc. has affected these regions.

Is this possible and what are any such means in which these regions of the face can change?

This isn't a personal medical question as this is widely applicable and generic to any human adult.

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  • $\begingroup$ Possibly many things can affect the morphology but the question is whether they are controllable in any manner like a surgery. Can you please elaborate your question and try to keep it to the point such that it can be answered in a few paragraphs? $\endgroup$
    – WYSIWYG
    Commented Feb 26, 2019 at 10:22
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    $\begingroup$ There's no way I can think of to better word/organize the question -- it's as simple and straight as I can get it. $\endgroup$
    – Fat Boy Jones
    Commented Feb 26, 2019 at 17:54

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Acromegaly (pituitary gigantism) is a disease that causes enlargement of the bones of the face. There is interest in computerizing facial measurements to catch subtle enlargements and prompt testing for the disease.

https://www.researchgate.net/publication/261409008_Three-dimensional_facial_analysis_in_acromegaly_a_novel_tool_to_quantify_craniofacial_characteristics_after_long-term_remission

Sixteen patients in remission of acromegaly for over 24 months (50 % male, mean age 56.0 ± 10.7 years, mean body mass index 29.3 ± 5.5 kg/m(2)) were compared to 16 matched control subjects. A 3D cone beam computed tomography scan and 3D stereophotograph of each individual were acquired and analyzed using 3D cephalometry. In addition to an accurate quantification of the classical craniofacial characteristics, 3D cephalometry, shows that many typical soft tissue deformities persist, even after long-term remission. Furthermore, we found that, compared to controls, the patients in remission of acromegaly have a wider face at the level of the zygoma and longer maxilla (p < 0.05)

Apocryphally, enlarging hat size goes along with acromegaly.

Pagets disease of bone causes enlargement of the skull and also an increase in hat size (so bitemporal dimension); the hat size increase was one of the chara eristics first described in the disease.

Thalassemia is a group of blood diseases characterized by ineffective red blood cell production. The body compensates by making more marrow anywhere it can. Some people wind up with expanded bones in the skull or maxilla as a result.

thalassemia faces https://www.slideshare.net/ismahharon/thalassemia-is

These are all systemic diseases that affect the bone. Of course one can have a tumor of bone (primary or metastatic) that expands it and changes the shape of the face or the head.

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