2
$\begingroup$

Since c-sis regulates only cell growth, a mutation there should only lead to an out of control growth of the cell, but the cells would still be mature, since c-sis does not regulate the function or maturing of the cell.

However a mutation in c-sis leads to cancer, and cancer is not just cells that grow out of control, but also don't performe their function (are not mature). Can someone explain how a c-sis mutation still leads to cancer please?

$\endgroup$
  • $\begingroup$ Hello and welcome to Biology.SE! Currently, the title of your question is quite broad, but the content of your question seems to focus on the c-sis oncogene. Are you expecting an answer only for the c-sis oncogene? If so, please be sure to edit the title of your question to reflect that. $\endgroup$ – TanMath Mar 1 at 1:35
  • $\begingroup$ Any oncogene that regulates growth only, I used c-sis oncogene as an example because that is the only one I know that has this function. I changed title, thanks for the feedback! $\endgroup$ – user9000 Mar 1 at 8:06
2
$\begingroup$

Cancer is not a disease like the flu or E. bola, where there is a single quick and easy cause for the disease which you can locate and describe in a single sentence. Cancer consists of malignant cell growth, it is true, but why are the cells growing out of control?

The fact is that there is not one single cause. At some point along the way, some cell experience a mutation to some gene which resulted in a slightly higher rate of proliferation than normal. However, this in and of itself is not even enough to produce a tumour. It simply gives the cells a higher number of daughter cells, and consequently, a higher risk of having more mutations.

At some point, one of those daughter cells acquires a mutation which results in higher levels yet of proliferation, or a mutation which encourages angiogenesis, or (in the case of epithelial cells, for instance) a mutation which allows the cell to escape typical anoikis pathways and perhaps perforate its basement membrane without dying.

Even the process of metastasis requires multiple mutations to happen, and yet if a tumour does not metastasize, it is typically regarded as benign. The point is, cancer is not caused by a single mutation to an oncogene or otherwise. It is caused by an accumulation of mutations which permit the cells to proliferate much faster than normal, to recruit the body's resources, and to live in tissues all around the body.

In the case of the particular gene that you mentioned, the exact role of the c-sis oncogene in cancer prevention is still unclear; in fact, according to the OMIM page,

The protein product of the c-sis gene has not been identified.

...though the gene is very similar to platelet derived growth factor genes, some of which have been identified as mitogenic factors. Theoretically, therefore, it is possible that a mutation to the c-sis results in excessive mitogenic stimulation, resulting in an increase in cell division and proliferation. But that last sentence is speculation, not hard science.

TL; DR:

We don't know, but it's possible c-sis encourages faster cell division.


Sources:

$\endgroup$

Your Answer

By clicking “Post Your Answer”, you agree to our terms of service, privacy policy and cookie policy

Not the answer you're looking for? Browse other questions tagged or ask your own question.