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Is it possible for an anti-cancer monoclonal antibody to target the two repressor domains in the N and C terminal of the TBX3 protein ?

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  • $\begingroup$ It is very unlikely that an antibody binds to two domains of a protein at the same time. If the two domains have a high structural similarity it might be possible that one TBX3 protein binds two identical antibodies. You could align the two domains and see if they have a common sequence stretch. If that's the case you could check if the stretch is unique, i.e. otherwise the antibody would bind to more than just RBX3. $\endgroup$ – Ashafix Mar 10 at 21:14
  • $\begingroup$ Hypothetical questions have been asked here and we consider them on-topic if sufficient background and rationale is provided. Can you please elaborate your question? As it stands, it looks like a primarily opinion-based question and is likely to be put on-hold. Moreover, because of the lack of background, your question is also a bit unclear. $\endgroup$ – WYSIWYG Mar 11 at 15:22

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