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Why is it that tandem repeats like CAGCAGCAG cause primer-template misalignment and diseases like Huntingtons disease? By my understanding, too many such repeats can cause strands to form hairpins and loops that fail to be replicated in the template strand, causing deletions. Is this correct?

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  • $\begingroup$ What research (see Help) have you done to try to find the answer to this question yourself? You should be able to find it very easily on the internet. $\endgroup$ – David Mar 11 at 13:30
  • $\begingroup$ Moreover, your question is unclear. Are you asking how these repeats increase or how they cause disease? $\endgroup$ – WYSIWYG Mar 12 at 17:04

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