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After reading a textbook chapter on GPCRs I am still confused by what regulates cAMP.

I took in my notes that cAMP is made by adenylyl cyclase and destroyed by cAMP phosphodiesterases (also another question within a question, are phosphodiesterases the same as phosphatases?)

So is cAMP regulated by GPCRs or is it regulated by cyclic AMP dependent Kinase A (PKA)?

I did find this article, but I'm not sure if I am understanding this correctly to answer my own question, but it seems like they are saying GPCRs regulate cAMP?

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2720142/

Thanks

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    $\begingroup$ Phosphodiesterases are not necessarily the same as the phosphatases. A phosphodiester has 2 ester linkages, like in DNA. So a phosphatase could specifically cut off phosphates with a single ester linkage while ignoring the phosphodiesters. $\endgroup$ – user137 Mar 19 at 3:21
  • $\begingroup$ Have you consulted a basic biochemistry text such as Berg et al (available on NCBI Bookshelf)? Start there. $\endgroup$ – David Mar 19 at 18:32
  • $\begingroup$ Not helpful as you do not provide a direct answer to my question or even provide the link to the text you are referencing. Here is a google search of Berg et al: google.com/… $\endgroup$ – user3665690 Mar 20 at 19:05

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