1
$\begingroup$

If both controls the expression of another gene by physically or genetically interacting with the target gene, which attributes make "Regulatory gene" different from "Modifier gene" or vice-versa?

$\endgroup$
  • $\begingroup$ Leaving a comment when down voting would help. I upvoted. $\endgroup$ – Remi.b Mar 23 at 21:34
1
$\begingroup$

Different terms in different fields

I think that the two concepts are very similar but are used in different fields. The term "modifier genes" is often used in quantitative genetics and in evolutionary genetics while the term "regulatory gene" is often used in molecular genetics.

Example of a modifier gene that is not a regulatory gene

The concept of modifier gene can also be used in modelling when considering genes that "modify" the recombination rate (e.g. Otto and Barton, 2007; or other properties of the genome) in a quantitative manner. As such, a modifier gene is not really a regulatory gene (as it does not regulate the expression of another gene). As such I consider definitions like this one from ndsu as being too restrictive.

What I think about when I hear these terms

I would tend to think as a modifier as a more general concept than the concept of regulatory gene. Also, when I think of a regulatory gene, I think of this gene by the mechanism by which it affects other genes while when I think of a modifier gene, I think of the statistical effect of this gene on genetic properties of the organism.

$\endgroup$
  • $\begingroup$ Thnx for ur comment @Remi.b. Can it be that "regulatory gene" does not have any functional phenotype? It just can modify another gene? On the other hand "modifier gene" has its own functional phenotype and at the same time, it can have an epistatic relationship with another gene? $\endgroup$ – Tahsin Hassan Rahit Mar 23 at 22:05
  • $\begingroup$ I am not sure I understood your comment but please see edit in my answer. $\endgroup$ – Remi.b Mar 23 at 22:21

Your Answer

By clicking “Post Your Answer”, you agree to our terms of service, privacy policy and cookie policy

Not the answer you're looking for? Browse other questions tagged or ask your own question.