When Dolly was cloned, it was not from a totipotent cell in an early embryo but a G0 phase induced cell originating from the donor sheep's mammary glands. I have found sources stating that a fully differentiated cell was induced into the G0 phase by serum-starvation but couldn't find any further information on what happens inside the serum-starved cell that arrests it in the G0 phase.

Question: What is the cellular response mechanism behind serum-starvation induced G0 phase arrest? and How is it that this fully grown cell(even though it may be in G0 phase) or rather the chromosomes in that cell behave like a totipotent cell and divide to form a complete embryo when the nucleus is injected into an egg cell with the nucleus removed?


Your Answer

By clicking “Post Your Answer”, you agree to our terms of service, privacy policy and cookie policy

Browse other questions tagged or ask your own question.