What does “crude” mean in this context?

Question

Taken from Ian Freshney's Culture of Animal Cells:

The enzymes used most frequently for tissue disaggregation are crude preparations of trypsin, collagenase, elastase, pronase, Dispase, DNase, and hyaluronidase...

What does crude mean in this context?

Answer 1

In this context crude means naturally occurring or unrefined.

Purified trypsin alone, for example, is usually ineffective for tissue dissociation since it shows little selectivity for extracellular proteins.

Source: Worthington Tissue Dissociation Guide