Why would the body choose a resting temperature of 36.1c to 37.2c? It seems a very inefficient mechanism of survival considering the typical ambient temperatures on Earth. If there is a benefit to needing to continuously do extra work, what is it?


4 Answers 4


What's the benefit of the average human body temperature?

It's a balance between preventing infection and not requiring excessive food intake. It is has also been claimed that this is the temperature at which the most essential enzymes are most reactive, without becoming damaged by excess temperature.


"The number of fungal species that can thrive and therefore infect an animal declines by 6 percent for every 1° C rise in temperature. This means that tens of thousands of fungal species infect reptiles, amphibians and other cold-blooded animals, but only a few hundred harm mammals.".

It is useful to refer to ectotherms (an organism in which internal physiological sources of heat are of negligible importance in controlling body temperature, which permits them to operate at very economical metabolic rates) as poikilotherms when applicable.

"Poikilothermic animals include types of vertebrate animals, specifically some fish, amphibians, and reptiles, as well as a large number of invertebrate animals. The naked mole-rat is the only mammal that is currently thought to be poikilothermic.".

"Poikilotherm animals must be able to function over a wider range of temperatures than homeotherms. The speed of most chemical reactions vary with temperature, and in order to function poikilotherms may have four to ten enzyme systems that operate at different temperatures for an important chemical reaction. As a result, poikilotherms often have larger, more complex genomes than homeotherms in the same ecological niche. Frogs are a notable example of this effect, though their complex development is also an important factor in their large genome.

Because their metabolism is variable and generally below that of homeothermic animals, sustained high-energy activities like powered flight in large animals or maintaining a large brain is generally beyond poikilotherm animals. The metabolism of poikilotherms favors strategies such as sit-and-wait hunting over chasing prey for larger animals with high movement cost. As they do not use their metabolisms to heat or cool themselves, total energy requirement over time is low. For the same body weight, poikilotherms need only 5 to 10% of the energy of homeotherms.".

Poikilotherms vs. Invertebrates

This update speaks to the theories on enzymes (solitary from metabolism), offered in other answers.

Articles and theories that are not discredited:

  • Enzyme assays by Hans Bisswanger:

    That article is mostly concerned with the temperature used to conduct assays of enzymes.

    "The essential requirements for enzyme assays are described and frequently occurring errors and pitfalls as well as their avoidance are discussed. The main factors, which must be considered for assaying enzymes, are temperature, pH, ionic strength and the proper concentrations of the essential components like substrates and enzymes. Standardization of these parameters would be desirable, but the diversity of the features of different enzymes prevents unification of assay conditions. Nevertheless, many enzymes, especially those from mammalian sources, possess a pH optimum near the physiological pH of 7.5, and the body temperature of about 37 °C can serve as assay temperature, although because of experimental reasons frequently 25 °C is preferred. But in many cases the particular features of the individual enzyme dictate special assay conditions, which can deviate considerably from recommended conditions.".


    "Enzymes display their highest activity at their respective optimum conditions, deviations from the optimum cause a reduction of the activity, depending on the degree of the deviation. Moderate deviations produce only small activity decreases which can be tolerated (Figure 1), and so the physiological conditions prevailing in the cell may be taken as standards for at least of the mammalian enzymes. However, assay procedures are usually adapted directly to the features of the individual enzyme and not to obey general standards. Enzymes are sensitive substances present in small amounts and their activity in the cell can often be detected only at their optimum conditions.".

  • Royal Society of Chemistry - "Enzymes - Function and structure":

    "As the temperature rises, reacting molecules have more and more kinetic energy. This increases the chances of a successful collision and so the rate increases. There is a certain temperature at which an enzyme's catalytic activity is at its greatest (see graph). This optimal temperature is usually around human body temperature (37.5 °C) for the enzymes in human cells.

    Above this temperature the enzyme structure begins to break down (denature) since at higher temperatures intra- and intermolecular bonds are broken as the enzyme molecules gain even more kinetic energy.". Enzyme activity temperature

Note: Wikipedia: "Wilson's temperature syndrome":

"The American Thyroid Association (ATA) describes Wilson's syndrome as at odds with established knowledge of thyroid function. The ATA described the diagnostic criteria for Wilson's syndrome as imprecise and non-specific, and raised concern that the proposed treatments were potentially harmful. Florida State Medical Board members described Wilson's syndrome as a "phony syndrome" and a scam during disciplinary action against Wilson."


"The ATA stated in 2005 that a "thorough review of the biomedical literature has found no scientific evidence supporting the existence of 'Wilson's Temperature Syndrome'." The statement added that the mean temperature of normal persons in the AM on waking is 97.5 °F, not 98.5 °F, and that many of the symptoms described by Wilson are nonspecific and typical of depression, anxiety, and psychological and social stress. It also notes that a similar set of symptoms occurs in the alternative diagnoses of neurasthenia, chronic fatigue syndrome, fibromyalgia, multiple chemical sensitivity, chronic Epstein-Barr virus syndrome, and chronic candidiasis. Finally, the Association notes that chronic supplementation with triiodothyronine (T3) is particularly difficult and problematic, since various tissues set their own cellular levels of this hormone by making it individually from thyroxine, and supplementation of T3 may overwhelm this normal regulatory mechanism in some of these tissue.".

Reference: Wilson's Temperature Syndrome

"... when an enzyme-dependent chemical reaction is monitored for how well it takes place at various temperatures, the lower the temperature, the slower the chemical reaction. As the temperature is increased, the reaction rate will go faster with each increase until it reaches its optimum reaction rate. If the temperature is increased too much, the rate of reaction will diminish due to denaturing or change in shape of the enzyme.".

The treatment suggested by Wilson is what was discredited, the fact that enzyme reactions proceed differently at different temperatures is still supported. Reference to his article was included due to the partial overlap with established knowledge.

  • 1
    $\begingroup$ I think you are the only one that answered the rather indirect question of why body temperatures are above ambient. $\endgroup$
    – user40950
    Apr 9, 2019 at 12:21
  • $\begingroup$ Those are some interesting citations, but I think this answer misses the other advantages of an elevated body temperature. $\endgroup$
    – Bryan Krause
    Apr 9, 2019 at 16:15
  • 1
    $\begingroup$ @BryanKrause I am expanding my answer. $\endgroup$
    – Rob
    Apr 9, 2019 at 17:50
  • $\begingroup$ Interesting. I was hypothesizing that perhaps our DNA developed in a warmer environment and we developed adaptations for cooler environments. Is there any possibility of that scenario? $\endgroup$ Apr 9, 2019 at 21:26
  • 1
    $\begingroup$ @NonSecwitter I've made another update, I believe it explains that. Poikilotherms adapted to be conservative while homeotherms adapted to high energy activities and maintaining a larger brain. I think your 'DNA question' deserves its own space, but the short answer is that each developed its own taxa in either environment. $\endgroup$
    – Rob
    Apr 9, 2019 at 22:11

Consider if cavemen would be efficient at defending and fighting each other and predators if they took 15 minutes to warm up from a cold nap before they can start to move.

Animals with wider temperature ranges have to maintain many enzyme genes for enzymes that work at different temperatures, and that's inefficient.

If an animal is warm, it processes food and grows a lot faster, so it makes sense for all growing animals to be warm day and night if they can. Older animals can build up fat and reserves and milk and offspring faster if they are resting warmly also. So a female human would benefit from being warm from age 0-37 to breed.

Bears can be dormant at 33'C and alaskan marmots can adjust to 3'C. Humans that don't hybernate have to be active every day, and have to survive the nights, and grow fast, and build up fat reserves, and keep the immune system enzymes and antibodies at their most performant.

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First, let's learn about the vocabulary to describe how living beings deal with their internal temperature with this answer. Now that you have read this answer, you understand that humans are homeo-endo-therms.

There are pros and cons of homeothermy. Those pros and cons depend upon the species and esp. upon the type of environment experienced by the organism. Here is one pro and one con. In the specialized literature, you;d find a much more exhaustive list of pros and cons


The activity of most chemical reactions are affected by temperature. See this post, this post and this post for examples (this post might also be of interest). Enzyme activities are typically highly dependent upon the temperature.

Homeotherms have the advantage that their internal working is not too affected by the outside temperature allowing them to maintain a high metabolism and a high level of activity in a variety of environmental conditions.


Depending upon the environment and the species, it may take a lot of energy (and other ressources) to maintain a constant temperature. For example, in mammals we see behaviours such as shivering, hair positioning (piloerection), vasoconstriction, sweating, change in body posture and other systems such as non-shivering heat production by brown adipose tissues.


You perhaps need to consider that it's not just humans. All mammals have body temperatures in a fairly narrow range - 97-103 °F/36-39.5 °C. Birds likewise have a narrow temperature range, though a bit higher, around 105 °F/40.5 °C.

The advantages seem fairly obvious, at least if you've seen reptiles in cold weather torpor. As another answer points out, the speed of chemical reactions varies with temperature. Maintaining a constant temperature allows those reactions (which ultimately determine the speeed of everything the body does) to happen at a constant rate, so animals can be equally active in everything from polar ice to tropical jungle.


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