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Can someone please explain what does 'fixing' of an antigen presenting cell mean?

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    $\begingroup$ In which context did you find this term? $\endgroup$ – Chris Apr 17 '19 at 21:09
  • $\begingroup$ in the chapter of MHC and APC (Kuby). $\endgroup$ – MONIS MUSHTAQUE Apr 21 '19 at 13:58
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    $\begingroup$ You can also read about purpose and the procedure of hostological fixation: en.m.wikipedia.org/wiki/Fixation_(histology) $\endgroup$ – KaPy3141 Jun 8 at 14:06
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According to this paper, fixation of an antigen presenting cell refers to the exposure of antigen presenting cells to paraformaldehyde prior to immunostaining. This treatment is used to aggregate membrane proteins and strengthen the intercellular transient protein-protein interaction.

Resource

Barisas BG, Wade WF, Jovin TM, Arndt-Jovin D, Roess DA. Dynamics of molecules involved in antigen presentation: effects of fixation. Mol Immunol. 1999 Aug;36(11-12):701-8. doi: 10.1016/s0161-5890(99)00091-7. PMID: 10593509.

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