Starting a new project on protein-protein interactions and SNP analysis tool development. I would like to ask how does SNPs is mapped into protein? What does mapping means?

  • $\begingroup$ I assume SNP means Single-Nucleotide Polymorphism? I'm confused exactly what your question is - how does one take a SNP and see what effect it has on the protein sequence? Is that it? $\endgroup$ – MattDMo May 13 '13 at 20:48

Well SNPs are single nucleotide polymorphisms. Some SNPs are in the coding regions of genes and they can result in changes in the resulting protein. For example, the SNP rs1801131 is a human variation where some individuals have a G instead of an A at position 1515 of the gene MTHFR. When the gene is transcribed and then translated into protein, this variation (the presence of the G nucleotide) causes a Glutamate residue at position 429 of the protein to be a Glycine instead.

So, SNP rs1801131 maps to position 429 of the protein MTHFR.

  • $\begingroup$ @MattDMo you've got a dirty mind... :) $\endgroup$ – terdon May 14 '13 at 9:51

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