I know that as volumes of distribution increase they correspond to the blood, then the vascular rich group (heart, kidneys, liver, brain if BBB permeable), then muscle then adipose. But things like flow should also be taken into account. So are drugs usually distributed in a similar manner to blood, vascular rich group, etc?
How are drugs distributed into any tissue, and what affects it? Note that there are no general answers, and that this is highly dependent on the drug in question.
Active or passive transport
Is your drug a substrate for any uptake or efflux transporters that may affect the distribution?
Lipophilic drugs will generally have a greater volume of distribution, as there is more passive diffusion into tissue.
How much drug is presented to the area in question? Tissue with greater perfusion (e.g. kidneys) will have a greater exposure to the drug. Look up the well-stirred model.
Relating this to the blood marrow
So what should you research in order to answer your question?
- What are the physiochemical properties of the drug in question? How are these compared to other drugs where the bone marrow is a target?
- Is the drug a substrate for any relevant transporters in the tissue of interest?
You should also look up if there are any physiologically-based pharmacokinetic (PBPK) models for your drug or drugs with similair physiochemical properties. Some of these are free, and allow you to make general assumptions about the distribution of the drug.