How is the duration of cell cycle influenced by the concentration in nutrients, mechanical constraint, temperature or other factors ?

And can it change strongly ? Meaning there are 2 possibilities, for example in a case when we decrease slowly the concentration in $O_2$ in the medium :

  1. either the cell increases slowly the duration time until it's very long as if the cell cycle was stopped,
  2. or when the cell cycle is "working", it's more or less the same duration, and when the conditions don't fit anymore, the duration becomes abruptly very very long and the cell enters all of a sudden in quiescence.

I assume as always in biology it strongly depends on the type of cells and many other factors, but I'll be glad to get any hint about that question.

Thx in advance


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