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Fusion genes should have an origin.These are essentially hybrid genes that are translocated in its entirety. Eg. BCR-ABL, EML4-ALK are known to be implicated in cancer pathogenesis. Do these translocation events occur somatically or is there a possibility for it to be inherited?

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  • $\begingroup$ What do you mean by fusion genes? Can you please add some context? At the moment it is unclear what you are trying to ask. $\endgroup$ – WYSIWYG May 15 at 11:54
  • $\begingroup$ Hybrid genes that are translocated in its entirety. Eg. BCR-ABL, EML4-ALK are known to be implicated in cancer pathogenesis. Do these translocation events occur somatically or is there a possibility for it to be inherited? $\endgroup$ – Aishwarya Parasuram May 15 at 12:10
  • $\begingroup$ Hi and Welcome to Stack exchange. I think your question is not properly phrased. These hybrid genes you mention are indeed related to carcinogenesis, as in they are mutations commonly found in specific cancer types. It is unclear whether you are asking if (any) translocation events can also occur in the germline, or whether cancer-associated translocation mutations (such as the Bcr-Abl, Tpr-Met or Gag-Onc) can occur in the germline, and thus be inherited. $\endgroup$ – Athe May 16 at 11:48
  • $\begingroup$ Thank you. Sorrry if it wasn't clear. I'm asking if cancer-associated translocation mutations (such as the Bcr-Abl, Tpr-Met or Gag-Onc) can occur in the germline, and thus be inherited. ?If yes, do you have papers supporting this? I haven't been able to find germline origin fusion genes. $\endgroup$ – Aishwarya Parasuram May 17 at 7:47

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